Boris E Acevedo Selected Research

CIGB-300

4/2012	Sensitivity of tumor cells towards CIGB-300 anticancer peptide relies on its nucleolar localization.
10/2010	Proteomic profile regulated by the anticancer peptide CIGB-300 in non-small cell lung cancer (NSCLC) cells.
5/2009	Safety and preliminary efficacy data of a novel casein kinase 2 (CK2) peptide inhibitor administered intralesionally at four dose levels in patients with cervical malignancies.
5/2009	Anticancer peptide CIGB-300 binds to nucleophosmin/B23, impairs its CK2-mediated phosphorylation, and leads to apoptosis through its nucleolar disassembly activity.
1/2008	Systemic administration of a peptide that impairs the protein kinase (CK2) phosphorylation reduces solid tumor growth in mice.

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Boris E Acevedo Research Topics

Disease

5	Neoplasms (Cancer) 04/2012 - 01/2007
2	Lung Neoplasms (Lung Cancer) 04/2012 - 10/2010
2	Neoplasm Metastasis (Metastasis) 10/2010 - 01/2007
1	Wounds and Injuries (Trauma) 01/2013
1	Diabetic Foot 01/2013
1	Ulcer 01/2013
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/2010
1	Lewis Lung Carcinoma 01/2007
1	Melanoma (Melanoma, Malignant) 01/2007
1	Carcinoma (Carcinomatosis) 01/2007

Drug/Important Bio-Agent (IBA)

5	CIGB-300IBA 04/2012 - 01/2008
5	Peptides (Polypeptides)IBA 04/2012 - 01/2008
2	Casein Kinase II (Casein Kinase 2)IBA 05/2009 - 01/2008
1	Epidermal Growth Factor (EGF)IBA 01/2013
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2013
1	Extracellular Matrix ProteinsIBA 01/2013
1	NucleophosminIBA 04/2012
1	Proteins (Proteins, Gene)FDA Link 10/2010
1	Antineoplastic Agents (Antineoplastics)IBA 10/2010
1	Viral DNAIBA 05/2009
1	Cell-Penetrating PeptidesIBA 01/2008
1	Cyclic PeptidesIBA 01/2008
1	Protein Isoforms (Isoforms)IBA 01/2007
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 01/2007
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2007
1	DNA (Deoxyribonucleic Acid)IBA 01/2007

Therapy/Procedure

4	Therapeutics 01/2013 - 01/2007
1	Surgical Amputation (Amputations) 01/2013